The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Commentary
Identifieur interne : 008966 ( Main/Exploration ); précédent : 008965; suivant : 008967The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Commentary
Auteurs : Robert J. Macfadyen [Royaume-Uni] ; M. Jennyfer Ng Kam Chuen [Royaume-Uni] ; Malcolm J. West [Australie] ; Paul J. Nestel [Australie] ; Adrienne C. Kirby [Australie] ; Renate Schnabel [Allemagne] ; David Sullivan [Australie] ; R. John Simes [Australie] ; Christine Pollicino [Australie] ; Edith Lubos [Allemagne] ; Thomas F. Münzel [Allemagne] ; Harvey D. White [Nouvelle-Zélande] ; Andrew M. Tonkin [Australie] ; Christoph Bickel [Allemagne] ; Laurence Tiret [France] ; Stefan Blankenberg [Allemagne]Source :
- European heart journal [ 0195-668X ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Pathologie de l'appareil circulatoire, Athérosclérose, Séquence N terminale, Fragment, Peptide BNP, Tissu, Inhibiteur, Metalloendopeptidases, Métalloprotéinase, Niveau, Prédicteur, Facteur prédictif, Prédiction, Pronostic, Evolution, Lipide, Facteur risque, Risque, Pravastatine, Appareil circulatoire, Cardiologie.
English descriptors
- KwdEn :
- Atherosclerosis, Brain natriuretic peptide, Cardiology, Cardiovascular disease, Circulatory system, Evolution, Fragment, Inhibitor, Level, Lipids, Metalloendopeptidases, Metalloproteinase, N terminal-Sequence, Pravastatin, Prediction, Predictive factor, Predictor, Prognosis, Risk, Risk factor, Tissue.
Abstract
Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3-36 months previously. Methods Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject and results pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies. Cases (n = 250) were defined as those who had a cardiovascular death, non-fatal myocardial infarction or stroke during the studies. Controls (n = 250) remained event-free for the same follow-up duration (average 2.5 years) as the matched cases. The relationships between cases and plasma NT-proBNP and TIMP-1 were adjusted for the LIPID risk score, treatment allocation and other biomarkers (CRP, IL-6 and white cell count), and examined using a multivariable conditional logistic regression model. NT-proBNP levels were significantly higher in the cases than in the controls [389 (152-864) vs. 198 (93-416) pg/mL, median (25%-75% percentiles), P< 0.001]. The odds ratio (OR) of recurrent cardiovascular events in individuals in the highest quartile was three times higher than those in the lowest quartile (95% confidence interval (Cl) 1.8-5.1; P < 0.001). Similarly, TIMP-1 levels were significantly higher among cases compared with controls (806 vs. 736 pg/mL, median: highest vs. lowest quartile: OR 2.8, 95% Cl 1.6-4.7; P < 0.001). After adjustment for the LIPID risk score, treatment with pravastatin and other biomarkers, both NT-proBNP and TIMP-1 predicted cardiovascular events significantly and independently of each other. Conclusion The study suggests that in subjects with stable ischaemic disease, NT-proBNP and TIMP-1 are independent predictive markers of coronary heart disease outcome.
Affiliations:
- Allemagne, Australie, France, Nouvelle-Zélande, Royaume-Uni
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Sydney
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John" last="Simes">R. John Simes</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>NHMRC Clinical Trials Centre, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Pollicino, Christine" sort="Pollicino, Christine" uniqKey="Pollicino C" first="Christine" last="Pollicino">Christine Pollicino</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>NHMRC Clinical Trials Centre, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Lubos, Edith" sort="Lubos, Edith" uniqKey="Lubos E" first="Edith" last="Lubos">Edith Lubos</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="Munzel, Thomas F" sort="Munzel, Thomas F" uniqKey="Munzel T" first="Thomas F." last="Münzel">Thomas F. Münzel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Green Lane Cardiovascular Service, Auckland City Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>12 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Heart Foundation</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bickel, Christoph" sort="Bickel, Christoph" uniqKey="Bickel C" first="Christoph" last="Bickel">Christoph Bickel</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Innere Abteilung, Bundeswehrzentralkrankenhaus</s1><s2>Koblenz</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Koblenz</wicri:noRegion><wicri:noRegion>Bundeswehrzentralkrankenhaus</wicri:noRegion><wicri:noRegion>Koblenz</wicri:noRegion></affiliation></author><author><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>INSERM U525, Faculte de Medecin Pitie-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0183087</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0183087 INIST</idno><idno type="RBID">Pascal:08-0183087</idno><idno type="wicri:Area/PascalFrancis/Corpus">003665</idno><idno type="wicri:Area/PascalFrancis/Curation">002981</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002E21</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002E21</idno><idno type="wicri:doubleKey">0195-668X:2008:Macfadyen R:the:value:of</idno><idno type="wicri:Area/Main/Merge">009235</idno><idno type="wicri:Area/Main/Curation">008966</idno><idno type="wicri:Area/Main/Exploration">008966</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Commentary</title><author><name sortKey="Macfadyen, Robert J" sort="Macfadyen, Robert J" uniqKey="Macfadyen R" first="Robert J." last="Macfadyen">Robert J. Macfadyen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine and Department of Cardiology, City Hospital, Dudley Road</s1><s2>Birmingham B18 7QH</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Birmingham B18 7QH</wicri:noRegion></affiliation></author><author><name sortKey="Ng Kam Chuen, M Jennyfer" sort="Ng Kam Chuen, M Jennyfer" uniqKey="Ng Kam Chuen M" first="M. Jennyfer" last="Ng Kam Chuen">M. Jennyfer Ng Kam Chuen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University Department of Medicine and Department of Cardiology, City Hospital, Dudley Road</s1><s2>Birmingham B18 7QH</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Birmingham B18 7QH</wicri:noRegion></affiliation></author><author><name sortKey="West, Malcolm J" sort="West, Malcolm J" uniqKey="West M" first="Malcolm J." last="West">Malcolm J. West</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Queensland</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>University of Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Nestel, Paul J" sort="Nestel, Paul J" uniqKey="Nestel P" first="Paul J." last="Nestel">Paul J. Nestel</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Baker Heart Research Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kirby, Adrienne C" sort="Kirby, Adrienne C" uniqKey="Kirby A" first="Adrienne C." last="Kirby">Adrienne C. Kirby</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>NHMRC Clinical Trials Centre, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Schnabel, Renate" sort="Schnabel, Renate" uniqKey="Schnabel R" first="Renate" last="Schnabel">Renate Schnabel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="Sullivan, David" sort="Sullivan, David" uniqKey="Sullivan D" first="David" last="Sullivan">David Sullivan</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Royal Prince Alfred Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R. John" last="Simes">R. John Simes</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>NHMRC Clinical Trials Centre, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Pollicino, Christine" sort="Pollicino, Christine" uniqKey="Pollicino C" first="Christine" last="Pollicino">Christine Pollicino</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>NHMRC Clinical Trials Centre, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Lubos, Edith" sort="Lubos, Edith" uniqKey="Lubos E" first="Edith" last="Lubos">Edith Lubos</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="Munzel, Thomas F" sort="Munzel, Thomas F" uniqKey="Munzel T" first="Thomas F." last="Münzel">Thomas F. Münzel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author><author><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Green Lane Cardiovascular Service, Auckland City Hospital</s1><s2>Auckland</s2><s3>NZL</s3><sZ>12 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>National Heart Foundation</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bickel, Christoph" sort="Bickel, Christoph" uniqKey="Bickel C" first="Christoph" last="Bickel">Christoph Bickel</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Innere Abteilung, Bundeswehrzentralkrankenhaus</s1><s2>Koblenz</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Koblenz</wicri:noRegion><wicri:noRegion>Bundeswehrzentralkrankenhaus</wicri:noRegion><wicri:noRegion>Koblenz</wicri:noRegion></affiliation></author><author><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>INSERM U525, Faculte de Medecin Pitie-Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medicine II, Johannes Gutenberg University, Langenbeckstr. 1</s1><s2>Mainz 55131</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>55131</wicri:noRegion><wicri:noRegion>Langenbeckstr. 1</wicri:noRegion><wicri:noRegion>Mainz 55131</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European heart journal</title><title level="j" type="abbreviated">Eur. heart j.</title><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term><term>Brain natriuretic peptide</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Circulatory system</term><term>Evolution</term><term>Fragment</term><term>Inhibitor</term><term>Level</term><term>Lipids</term><term>Metalloendopeptidases</term><term>Metalloproteinase</term><term>N terminal-Sequence</term><term>Pravastatin</term><term>Prediction</term><term>Predictive factor</term><term>Predictor</term><term>Prognosis</term><term>Risk</term><term>Risk factor</term><term>Tissue</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Athérosclérose</term><term>Séquence N terminale</term><term>Fragment</term><term>Peptide BNP</term><term>Tissu</term><term>Inhibiteur</term><term>Metalloendopeptidases</term><term>Métalloprotéinase</term><term>Niveau</term><term>Prédicteur</term><term>Facteur prédictif</term><term>Prédiction</term><term>Pronostic</term><term>Evolution</term><term>Lipide</term><term>Facteur risque</term><term>Risque</term><term>Pravastatine</term><term>Appareil circulatoire</term><term>Cardiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3-36 months previously. Methods Plasma NT-proBNP and TIMP-1 were measured in a nested case control study of 250 randomly matched subject and results pairs enrolled in the long-term intervention with pravastatin in ischaemic disease (LIPID) and LIPID extended follow-up studies. Cases (n = 250) were defined as those who had a cardiovascular death, non-fatal myocardial infarction or stroke during the studies. Controls (n = 250) remained event-free for the same follow-up duration (average 2.5 years) as the matched cases. The relationships between cases and plasma NT-proBNP and TIMP-1 were adjusted for the LIPID risk score, treatment allocation and other biomarkers (CRP, IL-6 and white cell count), and examined using a multivariable conditional logistic regression model. NT-proBNP levels were significantly higher in the cases than in the controls [389 (152-864) vs. 198 (93-416) pg/mL, median (25%-75% percentiles), P< 0.001]. The odds ratio (OR) of recurrent cardiovascular events in individuals in the highest quartile was three times higher than those in the lowest quartile (95% confidence interval (Cl) 1.8-5.1; P < 0.001). Similarly, TIMP-1 levels were significantly higher among cases compared with controls (806 vs. 736 pg/mL, median: highest vs. lowest quartile: OR 2.8, 95% Cl 1.6-4.7; P < 0.001). After adjustment for the LIPID risk score, treatment with pravastatin and other biomarkers, both NT-proBNP and TIMP-1 predicted cardiovascular events significantly and independently of each other. Conclusion The study suggests that in subjects with stable ischaemic disease, NT-proBNP and TIMP-1 are independent predictive markers of coronary heart disease outcome.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Macfadyen, Robert J" sort="Macfadyen, Robert J" uniqKey="Macfadyen R" first="Robert J." last="Macfadyen">Robert J. Macfadyen</name></noRegion><name sortKey="Ng Kam Chuen, M Jennyfer" sort="Ng Kam Chuen, M Jennyfer" uniqKey="Ng Kam Chuen M" first="M. Jennyfer" last="Ng Kam Chuen">M. Jennyfer Ng Kam Chuen</name></country><country name="Australie"><noRegion><name sortKey="West, Malcolm J" sort="West, Malcolm J" uniqKey="West M" first="Malcolm J." last="West">Malcolm J. West</name></noRegion><name sortKey="Kirby, Adrienne C" sort="Kirby, Adrienne C" uniqKey="Kirby A" first="Adrienne C." last="Kirby">Adrienne C. Kirby</name><name sortKey="Nestel, Paul J" sort="Nestel, Paul J" uniqKey="Nestel P" first="Paul J." last="Nestel">Paul J. Nestel</name><name sortKey="Pollicino, Christine" sort="Pollicino, Christine" uniqKey="Pollicino C" first="Christine" last="Pollicino">Christine Pollicino</name><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R. John" last="Simes">R. John Simes</name><name sortKey="Sullivan, David" sort="Sullivan, David" uniqKey="Sullivan D" first="David" last="Sullivan">David Sullivan</name><name sortKey="Tonkin, Andrew M" sort="Tonkin, Andrew M" uniqKey="Tonkin A" first="Andrew M." last="Tonkin">Andrew M. Tonkin</name></country><country name="Allemagne"><noRegion><name sortKey="Schnabel, Renate" sort="Schnabel, Renate" uniqKey="Schnabel R" first="Renate" last="Schnabel">Renate Schnabel</name></noRegion><name sortKey="Bickel, Christoph" sort="Bickel, Christoph" uniqKey="Bickel C" first="Christoph" last="Bickel">Christoph Bickel</name><name sortKey="Blankenberg, Stefan" sort="Blankenberg, Stefan" uniqKey="Blankenberg S" first="Stefan" last="Blankenberg">Stefan Blankenberg</name><name sortKey="Lubos, Edith" sort="Lubos, Edith" uniqKey="Lubos E" first="Edith" last="Lubos">Edith Lubos</name><name sortKey="Munzel, Thomas F" sort="Munzel, Thomas F" uniqKey="Munzel T" first="Thomas F." last="Münzel">Thomas F. Münzel</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="White, Harvey D" sort="White, Harvey D" uniqKey="White H" first="Harvey D." last="White">Harvey D. White</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Tiret, Laurence" sort="Tiret, Laurence" uniqKey="Tiret L" first="Laurence" last="Tiret">Laurence Tiret</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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